The therapeutic potential of Angiotensin-(1-7) as a novel Renin-Angiotensin System mediator

Mini Rev Med Chem. 2006 May;6(5):603-9. doi: 10.2174/138955706776876203.

Abstract

In this review, we show Angiotensin-(1-7) as a novel Renin Angiotensin System mediator that antagonizes cardiovascular and proliferative effects of Angiotensin II and exerts complex renal actions. We also speculate the possibility of new drugs for the treatment of cardiovascular, genitourinary and hepatic diseases by interfering with ACE2-Angiotensin-(1-7)-Mas axis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiotensin I / pharmacology
  • Angiotensin I / therapeutic use*
  • Animals
  • Genitalia, Male / drug effects
  • Humans
  • Liver / drug effects
  • Male
  • Peptide Fragments / pharmacology
  • Peptide Fragments / therapeutic use*
  • Rats
  • Renin-Angiotensin System / drug effects*

Substances

  • Peptide Fragments
  • Angiotensin I
  • angiotensin I (1-7)