Caulerpenyne-colchicine hybrid: synthesis and biological evaluation

Julien Bourdron; Laurent Commeiras; Pascale Barbier; Véronique Bourgarel-Rey; Eddy Pasquier; Nicolas Vanthuyne; Jean-Claude Hubaud; Vincent Peyrot; Jean-Luc Parrain

doi:10.1016/j.bmc.2006.04.024

Caulerpenyne-colchicine hybrid: synthesis and biological evaluation

Bioorg Med Chem. 2006 Aug 15;14(16):5540-8. doi: 10.1016/j.bmc.2006.04.024. Epub 2006 May 22.

Authors

Julien Bourdron¹, Laurent Commeiras, Pascale Barbier, Véronique Bourgarel-Rey, Eddy Pasquier, Nicolas Vanthuyne, Jean-Claude Hubaud, Vincent Peyrot, Jean-Luc Parrain

Affiliation

¹ UMR-CNRS 6178 SymBio, équipe Synthèse par voie Organométallique, Université Paul Cézanne (Aix-Marseille III), Marseille, France.

PMID: 16714115
DOI: 10.1016/j.bmc.2006.04.024

Abstract

The synthesis of an analog of caulerpenyne having a trimethoxyaryl moiety was achieved in 11% overall yield over 11 steps. Its biological activity has been evaluated as inhibitor of in vitro tubulin polymerization or angiogenesis.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Colchicine / analogs & derivatives
Colchicine / chemical synthesis
Colchicine / pharmacology*
Drug Screening Assays, Antitumor
Humans
Neovascularization, Physiologic / drug effects*
Neovascularization, Physiologic / physiology
Polymers / chemistry
Sesquiterpenes / chemical synthesis
Sesquiterpenes / pharmacology*
Structure-Activity Relationship
Tubulin / drug effects*
Tubulin / metabolism

Substances

Antineoplastic Agents
Polymers
Sesquiterpenes
Tubulin
caulerpenyne
Colchicine