Theoretical and experimental research, on the previously unresolved instability occurring along the slip stream of a shock-wave Mach reflection, is presented. Growth rates of the large-scale Kelvin-Helmholtz shear flow instability are used to model the evolution of the slip-stream instability in ideal gas, thus indicating secondary small-scale growth of the Kelvin-Helmholtz instability as the cause for the slip-stream thickening. The model is validated through experiments measuring the instability growth rates for a range of Mach numbers and reflection wedge angles. Good agreement is found for Reynolds numbers of Re 2 x 10(4). This work demonstrates, for the first time, the use of large-scale models of the Kelvin-Helmholtz instability in modeling secondary turbulent mixing in hydrodynamic flows, a methodology which could be further implemented in many important secondary mixing processes.