First report of a linezolid- and vancomycin-resistant Enterococcus faecium strain in Korea

Scand J Infect Dis. 2006;38(5):383-6. doi: 10.1080/00365540500372945.

Abstract

We report the first clinical isolate of linezolid- and vancomycin-resistant Enterococcus faecium (VREF) in Korea. The minimum inhibitory concentration of linezolid was in direct proportion to the number of copies of the G2576U mutation according to sequencing and restriction fragment length polymorphism analysis of the 23S rRNA gene.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / pharmacology*
  • Acetamides / therapeutic use
  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Base Sequence
  • Dose-Response Relationship, Drug
  • Drug Resistance, Multiple, Bacterial / genetics
  • Enterococcus faecium / drug effects*
  • Enterococcus faecium / genetics
  • Gram-Positive Bacterial Infections / drug therapy*
  • Gram-Positive Bacterial Infections / microbiology
  • Humans
  • Korea
  • Linezolid
  • Male
  • Microbial Sensitivity Tests
  • Mutation
  • Oxazolidinones / pharmacology*
  • Oxazolidinones / therapeutic use
  • Polymorphism, Restriction Fragment Length
  • Treatment Outcome
  • Vancomycin Resistance* / genetics

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Linezolid