Planar catechin analogues with alkyl side chains: a potent antioxidant and an alpha-glucosidase inhibitor

Wataru Hakamata; Ikuo Nakanishi; Yu Masuda; Takehiko Shimizu; Hajime Higuchi; Yuriko Nakamura; Shinichi Saito; Shiro Urano; Tadatake Oku; Toshihiko Ozawa; Nobuo Ikota; Naoki Miyata; Haruhiro Okuda; Kiyoshi Fukuhara

doi:10.1021/ja057763c

Planar catechin analogues with alkyl side chains: a potent antioxidant and an alpha-glucosidase inhibitor

J Am Chem Soc. 2006 May 24;128(20):6524-5. doi: 10.1021/ja057763c.

Authors

Wataru Hakamata¹, Ikuo Nakanishi, Yu Masuda, Takehiko Shimizu, Hajime Higuchi, Yuriko Nakamura, Shinichi Saito, Shiro Urano, Tadatake Oku, Toshihiko Ozawa, Nobuo Ikota, Naoki Miyata, Haruhiro Okuda, Kiyoshi Fukuhara

Affiliation

¹ Division of Organic Chemistry, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan.

PMID: 16704229
DOI: 10.1021/ja057763c

Abstract

Planar catechin analogues having various alkyl side chain lengths were synthesized, and their remarkable antioxidative abilities and alpha-glucosidase inhibitory activities are shown.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / pharmacology*
Catechin / analogs & derivatives*
Catechin / chemical synthesis
Catechin / pharmacology*
Geobacillus stearothermophilus / enzymology
Glycoside Hydrolase Inhibitors*
Saccharomyces cerevisiae / enzymology
alpha-Glucosidases

Substances

Antioxidants
Glycoside Hydrolase Inhibitors
Catechin
glucosidase I
alpha-Glucosidases