Immunological and immunogenetic markers in sporadic Alzheimer's disease

Aging Clin Exp Res. 2006 Apr;18(2):163-6. doi: 10.1007/BF03327434.

Abstract

Background: Common polymorphisms of genes controlling inflammation-modulating cytokines and acute-phase proteins which play important roles in the pathogenesis of Alzheimer's disease (AD) have been shown to be associated with AD.

Aims: The immunological and immunogenetic markers potentially useful for the AD risk evaluation and diagnosis are briefly reviewed.

Conclusion: The state-of-the-art of immunological and immunogenetic markers of AD indicates that new tools and strategies are necessary to identify gene products useful as diagnostic tools.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins / genetics
  • Acute-Phase Proteins / immunology
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / immunology*
  • Apolipoproteins E / genetics
  • Apolipoproteins E / immunology
  • Biomarkers / analysis*
  • Cytokines / genetics
  • Cytokines / immunology
  • DNA / analysis
  • Gene Expression Regulation / genetics
  • Gene Expression Regulation / immunology
  • Humans
  • Inflammation / blood
  • Inflammation / genetics
  • Inflammation / immunology
  • Microglia / pathology
  • Oligonucleotide Array Sequence Analysis
  • Polymorphism, Genetic
  • Positron-Emission Tomography

Substances

  • Acute-Phase Proteins
  • Apolipoproteins E
  • Biomarkers
  • Cytokines
  • DNA