Polymeric core-shell nanoparticles for therapeutics

Clin Exp Pharmacol Physiol. 2006 May-Jun;33(5-6):557-62. doi: 10.1111/j.1440-1681.2006.04408.x.

Abstract

1. Nanobiotechnologies have recently attracted significant attention from chemists, biologists, engineers and pharmaceutical scientists. In particular, they have been widely applied to improve drug, protein/peptide and gene delivery. 2. This review presents recent advances in the field of drug, protein/peptide and gene delivery using natural and synthetic polymer nanoparticles and explains how polymeric nanoparticles are specifically designed to suit the needs for targeted delivery of small molecular drugs, proteins/peptides and genes. In addition, some of the challenges and prospects for these technologies are discussed.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • DNA / chemistry
  • DNA / metabolism
  • Drug Carriers*
  • Humans
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / metabolism
  • Insulin / administration & dosage
  • Insulin / chemistry
  • Insulin / metabolism
  • Intestinal Absorption
  • Nanoparticles*
  • Nanotechnology / trends
  • Neoplasms, Experimental / genetics
  • Neoplasms, Experimental / metabolism
  • Polymers / chemistry*
  • Proteins / administration & dosage
  • Proteins / chemistry*
  • Proteins / metabolism
  • RNA, Small Interfering / chemistry
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / metabolism
  • Solubility
  • Technology, Pharmaceutical / trends
  • Transfection / methods
  • Vascular Endothelial Growth Factor Receptor-2 / genetics
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism

Substances

  • Drug Carriers
  • Hypoglycemic Agents
  • Insulin
  • Polymers
  • Proteins
  • RNA, Small Interfering
  • DNA
  • Vascular Endothelial Growth Factor Receptor-2