The case of an IgAk myeloma showed the following common features with more than a hundred of patients described by the literature: osteonecrosis of the jaws, prolonged administration of bisphosphonates due to neoplastic skeletal lesions, antitumoral therapies and recent dental surgery. The antiangiogenetic effects of bisphosphonates can have an important pathogenetic role and a general dental treatment should be completed before the start of bisphosphonate administration.