Age at diagnosis and loss of heterozygosity on chromosome 1p and 19q in oligodendroglial tumors

M Hergersberg; L Mariani; E Vassella; C Murtin; J Weis; M Moschopulos; H Laeng; H Landolt; A Huber; U Roelcke

doi:10.1007/s11060-006-9177-2

Age at diagnosis and loss of heterozygosity on chromosome 1p and 19q in oligodendroglial tumors

J Neurooncol. 2006 Nov;80(2):215-7. doi: 10.1007/s11060-006-9177-2. Epub 2006 May 10.

Authors

M Hergersberg, L Mariani, E Vassella, C Murtin, J Weis, M Moschopulos, H Laeng, H Landolt, A Huber, U Roelcke

PMID: 16685464
DOI: 10.1007/s11060-006-9177-2

Abstract

The age distribution and incidence of loss of heterozygosity (LOH) of 1p and 19q was analyzed in 85 oligodendroglial tumors WHO II and III. The peak of tumor manifestation was in the age group of 35 to 55 years. There was no association between age at diagnosis and LOH incidence. We conclude that the prognostic effect of age on survival is not mediated by LOH 1p/19q.

Publication types

Letter

MeSH terms

Adult
Age of Onset
Aging / physiology
Brain Neoplasms / diagnosis*
Brain Neoplasms / genetics*
Brain Neoplasms / pathology
Chromosomes, Human, Pair 1 / genetics*
Chromosomes, Human, Pair 19 / genetics*
Female
Humans
Loss of Heterozygosity / genetics*
Male
Middle Aged
O(6)-Methylguanine-DNA Methyltransferase / metabolism
Oligodendroglioma / diagnosis*
Oligodendroglioma / genetics*
Oligodendroglioma / pathology

Substances

O(6)-Methylguanine-DNA Methyltransferase