Synthesis and 5-HT receptors binding studies of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines

Farmaco. 1991 Dec;46(12):1435-47.

Abstract

The syntheses of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines are reported. The title compounds were tested for their potential activities on 5-HT receptor subtypes and 5-HT uptake site; compounds 4b-d showed micromolar affinity for 5-HT3 and 5-HT uptake site.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding, Competitive / drug effects
  • In Vitro Techniques
  • Ligands
  • Male
  • Paroxetine
  • Piperazines / chemical synthesis*
  • Piperazines / pharmacology
  • Piperidines / metabolism
  • Quinolones / chemical synthesis*
  • Quinolones / pharmacology
  • Quipazine / analogs & derivatives*
  • Quipazine / chemical synthesis
  • Quipazine / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Serotonin / metabolism*
  • Serotonin Antagonists*

Substances

  • Ligands
  • Piperazines
  • Piperidines
  • Quinolones
  • Serotonin Antagonists
  • Serotonin
  • Paroxetine
  • Quipazine