The title compound, [Cu8(C8H24O2Si)2(C3H7NO)8].C4H4N2.C3H7NO, features a sandwich-like cage enclosing a pyrazine molecule, both situated on a centre of inversion. In addition, the crystal structure contains one dimethylformamide molecule which is disordered over a centre of inversion. The copper layer, containing eight atoms, is located between two siloxanolate fragments. The whole structure of Cu atoms and siloxanolate rings is distorted by the pyrazine molecule, leading to an oval form. As a result, the angles between the Cu atoms differ at the copper layer. The difference in the angles could lead to some deviations in the Cu-Cu exchange interactions within the copper ring, which is of interest for molecular magnetism.