Our objective was to report on the clinical and radiological outcome from a cohort of patients with neuromuscular scoliosis who underwent selective anterior single rod instrumentation for correction of thoraco-lumbar and lumbar scoliosis. Traditionally combined anterior release with long posterior instrumentation has been advocated for the treatment of neuromuscular scoliosis. Neuromuscular curves tend to be long and may have significant pelvic obliquity. However, certain neuromuscular curves with minimal pelvic obliquity may lend themselves to selective anterior correction thereby saving motion segments and allow continued ambulation for those patients. Nine patients with neuromuscular scoliosis underwent selective anterior instrumentation between 1994 and 2000. The mean follow up was 2 years and 9 months (range 24-55 months). The clinical outcome (including parent and caregiver satisfaction), radiological outcome (Cobb angle, apical vertebral translation, pelvic obliquity, truncal shift, thoracic kyphosis, lumbar lordosis, sagittal vertical axis) and complications are reported. Subjective outcome was excellent in six patients and good in three. All nine patients retained their ability to walk. There were no neurological or vascular complications. Supplementary posterior surgery was required in two patients. The mean pre-operative Cobb angle of 52 degrees (range 44-60) improved to 20 degrees (range 10-28) at 3 months, achieving Cobb angle correction of 61% and was 19 degrees (range 7-28) at final follow-up. The mean pre-operative compensatory curve of 31 degrees (range 20-42) spontaneously corrected to 18 degrees (range 14-24) at 3 months and was maintained at 18 degrees (range 10-26) at final follow up. The mean pre-operative pelvic obliquity of 7 degrees (range 0-14) corrected to 4 degrees (range 0-8) at 3 months and was 3 degrees (range 0-8) at final follow up. Selective anterior instrumentation and fusion in carefully selected patients with neuromuscular scoliosis (short flexible curves, minimal pelvic obliquity, pre-operative walkers, slow or non-progressive pathology) appears to have satisfactory clinical and radiological outcome at least in the short-term.