PCR amplification of the IS6110 insertion element of Mycobacterium tuberculosis in fecal samples from patients with intestinal tuberculosis

J Clin Microbiol. 2006 May;44(5):1884-6. doi: 10.1128/JCM.44.5.1884-1886.2006.

Abstract

PCR amplification of insertion element IS6110 of Mycobacterium tuberculosis in fecal samples was evaluated in the diagnosis of intestinal tuberculosis (ITB). The numbers of samples that tested positive by PCR with SalI digestion were 16/18 untreated-ITB samples, 0/8 treated-ITB samples, 12/14 smear-positive pulmonary tuberculosis samples, and 0/30 control samples. The sensitivity, specificity, positive predictive value, and negative predictive value of fecal PCR were 88.8%, 100%, 100%, and 93.7%, respectively.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Case-Control Studies
  • DNA Transposable Elements
  • DNA, Bacterial / genetics
  • DNA, Bacterial / isolation & purification
  • Feces / microbiology
  • Humans
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / isolation & purification*
  • Polymerase Chain Reaction / methods*
  • Polymerase Chain Reaction / statistics & numerical data
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Tuberculosis, Gastrointestinal / diagnosis*
  • Tuberculosis, Gastrointestinal / microbiology*
  • Tuberculosis, Pulmonary / diagnosis
  • Tuberculosis, Pulmonary / microbiology

Substances

  • DNA Transposable Elements
  • DNA, Bacterial