Sensitivity of the Multispot HIV-1/HIV-2 rapid test using samples from human immunodeficiency virus type 1-positive individuals with various levels of exposure to highly active antiretroviral therapy

J Clin Microbiol. 2006 May;44(5):1831-3. doi: 10.1128/JCM.44.5.1831-1833.2006.

Abstract

The Multispot HIV-1/HIV-2 rapid test detects human immunodeficiency virus type 1 (HIV-1) gp41 antibodies, which can wane over time in some HIV-1-infected populations, resulting in false-negative screening results. Multispot sensitivity was 100% using 248 sera from one such population, and it correctly identified serostatus in individuals who previously tested false negative with rapid testing.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Antiretroviral Therapy, Highly Active
  • False Negative Reactions
  • Female
  • HIV Antibodies / analysis*
  • HIV Antibodies / blood
  • HIV Envelope Protein gp41 / immunology
  • HIV Infections / diagnosis*
  • HIV Infections / drug therapy
  • HIV Infections / immunology
  • HIV Infections / virology
  • HIV Seropositivity / diagnosis
  • HIV Seropositivity / immunology
  • HIV-1 / isolation & purification*
  • HIV-2 / isolation & purification*
  • Humans
  • Male
  • Middle Aged
  • Sensitivity and Specificity
  • Virology / methods*
  • Virology / statistics & numerical data

Substances

  • HIV Antibodies
  • HIV Envelope Protein gp41