Solid-phase synthesis of cyclic PNA and PNA-DNA chimeras

Org Lett. 2006 May 11;8(10):2015-8. doi: 10.1021/ol0603559.

Abstract

[structure: see text] A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide and phosphoramidite-based chemistry has been achieved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclization
  • DNA / chemical synthesis*
  • DNA / chemistry
  • Molecular Structure
  • Peptide Nucleic Acids / chemical synthesis*
  • Peptide Nucleic Acids / chemistry

Substances

  • Peptide Nucleic Acids
  • DNA