Effect of zosterin on protein-synthesizing activity of hepatocytes

Bull Exp Biol Med. 2005 Oct;140(4):425-7. doi: 10.1007/s10517-005-0510-0.

Abstract

The effect of zosterin (pectin polysaccharide) on the protein-synthesizing function of mouse liver cells was studied after its intragastric administration of 1% gel zosterin. The drug modified the morphology and function of the nucleolar apparatus by changing the number and summary area of the nucleoli, content of Ag proteins, nucleolar/nuclear ratio, and increased protein content in hepatocyte cytoplasm.

MeSH terms

  • Animals
  • Cell Nucleolus / drug effects
  • Cell Nucleus / chemistry
  • Cell Nucleus / drug effects
  • Cell Nucleus / genetics
  • Cytoplasm / chemistry
  • Cytoplasm / drug effects
  • Hepatocytes / cytology
  • Hepatocytes / drug effects*
  • Hepatocytes / metabolism
  • Liver / cytology
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Mice
  • Mice, Inbred Strains
  • Ploidies
  • Polysaccharides / pharmacology*
  • Protein Biosynthesis / drug effects*
  • Proteins / analysis

Substances

  • Polysaccharides
  • Proteins
  • zosterin