Free radical oxidation in rat brain during chronic stress and pharmacological regulation of this process

M A Kutlubaev; R R Farkhutdinov; L R Akhmadeeva; A F Mufazalov

doi:10.1007/s10517-005-0507-8

Free radical oxidation in rat brain during chronic stress and pharmacological regulation of this process

Bull Exp Biol Med. 2005 Oct;140(4):416-8. doi: 10.1007/s10517-005-0507-8.

Authors

M A Kutlubaev¹, R R Farkhutdinov, L R Akhmadeeva, A F Mufazalov

Affiliation

¹ Group of Biophysics, Central Research Laboratory, Bashkirian State Medical University, Ufa. mkmed@mail.ru

PMID: 16671569
DOI: 10.1007/s10517-005-0507-8

Abstract

We studied free radical oxidation in the brain and blood serum from experimental animals exposed to chronic stress and receiving psychotropic drugs (phenazepam, Atarax, Fluanxol, and valerian). Chronic stress was accompanied by activation of free radical oxidation, which could be modulated by psychotropic drugs.

MeSH terms

Animals
Brain / drug effects*
Brain / metabolism
Brain Chemistry
Free Radicals / toxicity*
Male
Oxidation-Reduction
Psychotropic Drugs / administration & dosage*
Rats
Stress, Physiological / drug therapy*
Stress, Physiological / metabolism
Thiobarbituric Acid Reactive Substances / analysis

Substances

Free Radicals
Psychotropic Drugs
Thiobarbituric Acid Reactive Substances