Direct asymmetric hydroxyamination reaction catalyzed by an axially chiral secondary amine catalyst

Taichi Kano; Mitsuhiro Ueda; Jun Takai; Keiji Maruoka

doi:10.1021/ja0604515

Direct asymmetric hydroxyamination reaction catalyzed by an axially chiral secondary amine catalyst

J Am Chem Soc. 2006 May 10;128(18):6046-7. doi: 10.1021/ja0604515.

Authors

Taichi Kano¹, Mitsuhiro Ueda, Jun Takai, Keiji Maruoka

Affiliation

¹ Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.

PMID: 16669668
DOI: 10.1021/ja0604515

Abstract

A direct asymmetric hydroxyamination reaction of aldehydes with nitrosobenzene was found to be catalyzed by the novel axially chiral secondary amine catalyst (S)-1d. The resulting optically enriched hydroxyamination products were readily converted to beta-amino alcohols or 1,2-diamines in one pot.