Transmission of extramembrane conformational change into current: construction of metal-gated ion channel

J Am Chem Soc. 2006 May 10;128(18):6010-1. doi: 10.1021/ja060515b.

Abstract

Interaction with Fe(III) induces the reversible conformational switch of the extramembrane segment in the artificial receptor channel, which is transmitted into membranes as an increase in channel current (ion flux).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alamethicin / chemistry*
  • Amino Acid Sequence
  • Circular Dichroism
  • Electrochemistry
  • Ferric Compounds / chemistry*
  • Ion Channel Gating
  • Ion Channels / chemical synthesis
  • Ion Channels / chemistry*
  • Leucine Zippers*
  • Molecular Conformation
  • Molecular Sequence Data
  • Protein Conformation
  • Proto-Oncogene Proteins c-fos / chemistry*

Substances

  • Ferric Compounds
  • Ion Channels
  • Proto-Oncogene Proteins c-fos
  • Alamethicin