Translating the concept of suppressor/regulatory T cells to clinical applications

Int Rev Immunol. 2006 Jan-Apr;25(1-2):27-47. doi: 10.1080/08830180500544506.

Abstract

The in vivo expansion of suppressor/regulatory T cells (Tregs) is a desirable event in autoimmunity and transplantation. Here we summarize the general rules involved in antigen recognition by T cells and describe Tregs and their requirements, discussing different levels of immune intervention.

Publication types

  • Review

MeSH terms

  • Antigens / immunology*
  • Autoimmune Diseases / immunology*
  • Autoimmunity*
  • Dendritic Cells / immunology
  • Humans
  • Immune Tolerance
  • Immunotherapy*
  • Ligands
  • Major Histocompatibility Complex / genetics
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / transplantation
  • Transplantation Tolerance / immunology

Substances

  • Antigens
  • Ligands