Abstract
Non-radioactive in situ hybridization of formalin-fixed paraffin-embedded placental and foetal tissue, using virus-specific DNA or RNA probes, may be helpful for the diagnosis of foetal virus infection causing foetal hydrops, granulomatous placentitis and abortion. We present four cases of intrauterine CMV-, Parvo-B19- and Varicella-Zoster virus infection, in which this diagnostic method established detection of the virus.
Publication types
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Case Reports
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Chickenpox / pathology
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Cytomegalovirus / isolation & purification
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Cytomegalovirus Infections / pathology
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DNA Probes*
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Endothelium, Vascular / pathology
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Female
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Fetal Diseases / pathology*
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Herpesvirus 3, Human / isolation & purification
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Humans
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Inclusion Bodies, Viral / ultrastructure
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Infant, Newborn
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Kidney / pathology
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Male
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Pancreas / pathology
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Parvoviridae Infections / pathology
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Parvovirus B19, Human / isolation & purification
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Placenta / pathology
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Pregnancy
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Pregnancy Complications, Infectious / pathology*
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Prenatal Diagnosis*
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RNA Probes*
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Virus Diseases / pathology*