Abstract
We present a 47-year-old Caucasian female who initially presented with mild discoid lupus erythematosus that evolved into systemic lupus erythematosus with subacute cutaneous LE and treatment-recalcitrant lupus panniculitis. Conventional therapy with antimalarials, systemic steroids, azathioprine, cyclophosphamide, methotrexate, and pulse doses of methylprednisolone did not control the course of the disease. Cyclosporin-A treatment led to clinical improvement and maintained remission.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimalarials / therapeutic use
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Azathioprine / therapeutic use
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Cyclophosphamide / therapeutic use
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Cyclosporine / therapeutic use*
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Disease Progression
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Drug Therapy, Combination
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Female
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Humans
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Hydroxychloroquine / therapeutic use
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Immunosuppressive Agents / therapeutic use
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Lupus Erythematosus, Systemic / drug therapy*
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Lupus Erythematosus, Systemic / etiology
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Lupus Erythematosus, Systemic / pathology*
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Methotrexate / therapeutic use
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Methylprednisolone / administration & dosage
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Methylprednisolone / therapeutic use
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Middle Aged
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Panniculitis, Lupus Erythematosus / complications
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Panniculitis, Lupus Erythematosus / drug therapy
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Panniculitis, Lupus Erythematosus / pathology*
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Pulse Therapy, Drug
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Tacrolimus / administration & dosage
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Treatment Failure
Substances
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Antimalarials
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Immunosuppressive Agents
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Hydroxychloroquine
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Cyclosporine
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Cyclophosphamide
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Azathioprine
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Tacrolimus
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Methylprednisolone
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Methotrexate