Abstract
Bioassay-directed fractionation using a glucocorticoid receptor assay led to the isolation of two new, weakly active polyprenylated acylphloroglucinol derivatives, sundaicumones A (1) and B (2), from the leaves of Calophyllum sundaicum collected in Singapore. The structures of 1 and 2, which were established by spectroscopic methods, contain a 3-substituted hexanoic acid unit not previously reported in other polyprenylated acylphloroglucinols.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Calophyllum / chemistry*
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Humans
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Molecular Structure
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Phloroglucinol* / analogs & derivatives
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Phloroglucinol* / chemistry
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Phloroglucinol* / isolation & purification
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Phloroglucinol* / pharmacology
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Receptors, Glucocorticoid / antagonists & inhibitors*
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Singapore
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Tumor Cells, Cultured
Substances
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Receptors, Glucocorticoid
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sundaicumone A
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sundaicumone B
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Phloroglucinol