Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllumsundaicum with weak activity against the glucocorticoid receptor

J Nat Prod. 2006 Apr;69(4):707-9. doi: 10.1021/np050528n.

Abstract

Bioassay-directed fractionation using a glucocorticoid receptor assay led to the isolation of two new, weakly active polyprenylated acylphloroglucinol derivatives, sundaicumones A (1) and B (2), from the leaves of Calophyllum sundaicum collected in Singapore. The structures of 1 and 2, which were established by spectroscopic methods, contain a 3-substituted hexanoic acid unit not previously reported in other polyprenylated acylphloroglucinols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calophyllum / chemistry*
  • Humans
  • Molecular Structure
  • Phloroglucinol* / analogs & derivatives
  • Phloroglucinol* / chemistry
  • Phloroglucinol* / isolation & purification
  • Phloroglucinol* / pharmacology
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Receptors, Glucocorticoid / antagonists & inhibitors*
  • Singapore
  • Tumor Cells, Cultured

Substances

  • Receptors, Glucocorticoid
  • sundaicumone A
  • sundaicumone B
  • Phloroglucinol