Aromatic constituents of Uvaria grandiflora

J Nat Prod. 2006 Apr;69(4):692-4. doi: 10.1021/np050500b.

Abstract

Grandiuvarone A (1) and grandiuvarins A-C (2-4) were isolated from the bark of Uvaria grandiflora. The structures of these new aromatic compounds were elucidated on the basis of spectroscopic analyses, especially 2D NMR techniques. Only compound 1 exhibited antileishmanial activity, with IC(50)/IC(90) values of 0.7/1.5 microg/mL. The positive controls pentamidine and amphotericin B had IC(50)/IC(90) values of 1.6/6.6 and 0.17/0.34 microg/mL, respectively.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amphotericin B / pharmacology
  • Animals
  • Antiprotozoal Agents* / chemistry
  • Antiprotozoal Agents* / isolation & purification
  • Antiprotozoal Agents* / pharmacology
  • Inhibitory Concentration 50
  • Leishmania / drug effects*
  • New Guinea
  • Oxepins* / chemistry
  • Oxepins* / isolation & purification
  • Oxepins* / pharmacology
  • Pentamidine / pharmacology
  • Plant Bark / chemistry
  • Plants, Medicinal / chemistry*
  • Uvaria / chemistry*

Substances

  • Antiprotozoal Agents
  • Oxepins
  • grandiuvarone A
  • Pentamidine
  • Amphotericin B