Abstract
Grandiuvarone A (1) and grandiuvarins A-C (2-4) were isolated from the bark of Uvaria grandiflora. The structures of these new aromatic compounds were elucidated on the basis of spectroscopic analyses, especially 2D NMR techniques. Only compound 1 exhibited antileishmanial activity, with IC(50)/IC(90) values of 0.7/1.5 microg/mL. The positive controls pentamidine and amphotericin B had IC(50)/IC(90) values of 1.6/6.6 and 0.17/0.34 microg/mL, respectively.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amphotericin B / pharmacology
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Animals
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Antiprotozoal Agents* / chemistry
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Antiprotozoal Agents* / isolation & purification
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Antiprotozoal Agents* / pharmacology
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Inhibitory Concentration 50
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Leishmania / drug effects*
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New Guinea
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Oxepins* / chemistry
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Oxepins* / isolation & purification
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Oxepins* / pharmacology
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Pentamidine / pharmacology
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Plant Bark / chemistry
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Plants, Medicinal / chemistry*
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Uvaria / chemistry*
Substances
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Antiprotozoal Agents
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Oxepins
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grandiuvarone A
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Pentamidine
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Amphotericin B