[Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors]

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2006 Mar;20(1):16-9.
[Article in Chinese]

Abstract

Background: To investigate variant genotyping of CCR2-64I, SDF1-3'A and CCR5Delta32 in HIV-1 infected Chinese Long-term nonprogressors and to study their association with disease progression.

Methods: The genotypes of CCR2-64I, SDF1-3'A and CCR5Delta32 were detected by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) assay in seventeen HIV-1 infected Chinese Long-term nonprogressors (LTNPs) and thirty-nine Chinese typical progressors (TPs).

Results: The frequency of CCR2-64I and SDF1-3'A in LTNPs are 50% and 62.5%, higher than those (23.08% and 33.33%) in TPs. Only one heterozygous CCR5 mutant was detected in LTNPs, and no CCR5 mutant in TPs.

Conclusion: Variant genotyping of CCR2-64ISDF1-3'A and CCR5Delta32 may be protective factors for delaying disease progression in HIV-1 infected Chinese LTNPs.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemokine CXCL12 / genetics*
  • China
  • Gene Frequency
  • Genotype
  • HIV Infections / genetics*
  • HIV Infections / pathology
  • HIV Infections / virology
  • HIV Long-Term Survivors*
  • HIV-1 / physiology*
  • Host-Pathogen Interactions
  • Humans
  • Mutation
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Receptors, CCR2 / genetics
  • Receptors, CCR5 / genetics
  • Receptors, HIV / genetics*

Substances

  • Chemokine CXCL12
  • Receptors, CCR2
  • Receptors, CCR5
  • Receptors, HIV