Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobacterium tuberculosis isolates

Claudia Plinke; Sabine Rüsch-Gerdes; Stefan Niemann

doi:10.1128/AAC.50.5.1900-1902.2006

Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobacterium tuberculosis isolates

Antimicrob Agents Chemother. 2006 May;50(5):1900-2. doi: 10.1128/AAC.50.5.1900-1902.2006.

Authors

Claudia Plinke¹, Sabine Rüsch-Gerdes, Stefan Niemann

Affiliation

¹ Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, D-23845 Borstel, Germany.

Abstract

We analyzed 159 Mycobacterium tuberculosis isolates (101 ethambutol [EMB]-resistant strains, 33 multidrug-resistant but not EMB-resistant strains, and 25 fully susceptible strains) for the presence of mutations in embB codon 306 (embB306). Mutations were detected only in EMB-resistant strains (n = 69; 68%), thus confirming the significance of embB306 mutations for the prediction of resistance to EMB.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / pharmacology*
Codon / genetics*
Drug Resistance, Bacterial / genetics*
Ethambutol / pharmacology*
Genes, Bacterial
Humans
Mutation*
Mycobacterium tuberculosis / drug effects
Mycobacterium tuberculosis / genetics*
Mycobacterium tuberculosis / isolation & purification

Substances

Antitubercular Agents
Codon
Ethambutol