Streptococcus pneumoniae isolates resistant to telithromycin

M Rantala; M Haanperä-Heikkinen; M Lindgren; H Seppälä; P Huovinen; J Jalava

doi:10.1128/AAC.50.5.1855-1858.2006

Streptococcus pneumoniae isolates resistant to telithromycin

Antimicrob Agents Chemother. 2006 May;50(5):1855-8. doi: 10.1128/AAC.50.5.1855-1858.2006.

Authors

M Rantala¹, M Haanperä-Heikkinen, M Lindgren, H Seppälä, P Huovinen, J Jalava

Affiliation

¹ Laboratory of Human Microbial Ecology, National Public Health Institute, Kiinamyllynkatu 13, FIN-20520 Turku, Finland. merja.rantala@ktl.fi

Abstract

The telithromycin susceptibility of 210 erythromycin-resistant pneumococci was tested with the agar diffusion method. Twenty-six erm(B)-positive isolates showed heterogeneous resistance to telithromycin, which was manifested by the presence of colonies inside the inhibition zone. When these cells were cultured and tested, they showed stable, homogeneous, and high-level resistance to telithromycin.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Base Sequence
Drug Resistance, Microbial / genetics*
Genes, Bacterial
Humans
Ketolides / pharmacology*
Macrolides / pharmacology*
Microbial Sensitivity Tests
Molecular Sequence Data
Promoter Regions, Genetic
Streptococcus pneumoniae / drug effects*
Streptococcus pneumoniae / isolation & purification
Streptococcus pneumoniae / physiology

Substances

Anti-Bacterial Agents
Ketolides
Macrolides
telithromycin

Associated data

GENBANK/AM180135
GENBANK/AM180136