Identification of a novel 120 bp allele at the TNFd microsatellite locus

I J Wastowski; N T A Peres; R T Simões; E C Castelli; A L Simões; N M Martinez-Rossi; E A Donadi

doi:10.1111/j.1399-0039.2006.00565.x

Identification of a novel 120 bp allele at the TNFd microsatellite locus

Tissue Antigens. 2006 Apr;67(4):318-20. doi: 10.1111/j.1399-0039.2006.00565.x.

Authors

I J Wastowski¹, N T A Peres, R T Simões, E C Castelli, A L Simões, N M Martinez-Rossi, E A Donadi

Affiliation

¹ Program of Basic and Applied Immunology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, Sp, Brazil.

PMID: 16634868
DOI: 10.1111/j.1399-0039.2006.00565.x

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine mainly secreted by macrophages and T-cells that play a key role in the pathogenesis of many infectious and inflammatory diseases. The TNF gene cluster is located within the class-III region of the highly polymorphic major histocompatibility complex on human chromosome 6p21. A cluster of six multiallelic microsatellites has been identified in the TNF region, named TNF a-e. TNFb, TNFc, TNFd, and TNFe are (GA)n repeats, whereas TNFa and TNFf are (GT)n and (CA)n repeats, respectively. The TNFd microsatellite locus maps 8-10 kb centromeric to the TNF-alpha gene, downstream to the TNF-beta gene.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Base Sequence
Chromosomes, Human, Pair 6 / genetics
Female
Genetic Markers
Humans
Microsatellite Repeats / genetics*
Middle Aged
Molecular Sequence Data
Multigene Family / genetics*
Scleroderma, Systemic / genetics
Tumor Necrosis Factor-alpha / classification
Tumor Necrosis Factor-alpha / genetics*

Substances

Genetic Markers
TNF protein, human
Tumor Necrosis Factor-alpha