Abstract
2alpha,7beta,20alpha-Trihydroxy-3beta,21-dimethoxy-5-pregnene (1), 6,7,9alpha-trihydroxy-3,8,11alpha-trimethylcyclohexo-[d,e]-coumarin (2), 3beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid (3), and 3beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid methyl ester (4), along with 24 known compounds were isolated and structurally characterized from roots and aerial parts of Helicteres angustifolia (Sterculiaceae). In a preliminary bioassay, the two cucurbitacin derivatives, cucurbitacin D and J exhibited significant inhibitory activities against the growth of both hepatocellular carcinoma BEL-7402 cells and malignant melanoma SK-MEL-28 cells in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Coumarins / chemistry*
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Coumarins / isolation & purification
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Coumarins / pharmacology
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Humans
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Malvaceae / chemistry*
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Molecular Conformation
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Nuclear Magnetic Resonance, Biomolecular
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Plant Components, Aerial / chemistry
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Plant Roots / chemistry
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Pregnanes / chemistry*
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Pregnanes / isolation & purification
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Pregnanes / pharmacology
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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Antineoplastic Agents
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Coumarins
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Pregnanes
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Triterpenes
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lupane
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coumarin