Immunosuppressive diacetylenes, ceramides and cerebrosides from Hydrocotyle leucocephala

Freddy Ramos; Yoshihisa Takaishi; Kazuyoshi Kawazoe; Coralia Osorio; Carmenza Duque; Ricardo Acuña; Yoshinori Fujimoto; Mitsunobu Sato; Masato Okamoto; Tetsuya Oshikawa; Sharif Uddin Ahmed

doi:10.1016/j.phytochem.2006.03.004

Immunosuppressive diacetylenes, ceramides and cerebrosides from Hydrocotyle leucocephala

Phytochemistry. 2006 Jun;67(11):1143-50. doi: 10.1016/j.phytochem.2006.03.004. Epub 2006 May 2.

Authors

Freddy Ramos¹, Yoshihisa Takaishi, Kazuyoshi Kawazoe, Coralia Osorio, Carmenza Duque, Ricardo Acuña, Yoshinori Fujimoto, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa, Sharif Uddin Ahmed

Affiliation

¹ Pharmacognosy Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomashi 1-78, Tokushima 770-8505, Japan.

PMID: 16631830
DOI: 10.1016/j.phytochem.2006.03.004

Abstract

Three C-17 diacetylenic compounds (1-3), one monoterpenoid (4), seven ceramides (leucoceramides A-G, 5a-g), six cerebrosides (leucocerebrosides A-F, 6a-f) and nine known compounds were isolated from the methanolic extract of Hydrocotyle leucocephala. Their structures were established by spectroscopic methods. The isolated compounds 1-3, 5a-g, 6a-f and 7 were shown to be active in the lipopolysaccharide (LPS) induced cytokine production assay for IL-10, IL-12, and TNF-alpha.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylene / chemistry*
Acetylene / pharmacology
Centella / chemistry*
Ceramides / chemistry*
Cerebrosides / chemistry*
Cytokines / biosynthesis
Cytokines / drug effects
Humans
Immunosuppressive Agents / chemistry*
Immunosuppressive Agents / pharmacology
Leukocytes, Mononuclear / drug effects
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Components, Aerial / chemistry

Substances

Ceramides
Cerebrosides
Cytokines
Immunosuppressive Agents
Acetylene