Abstract
In a recent issue of Molecular Cell, Studer and Joseph (2006) clarified the molecular basis of the "standby model" and demonstrated how two-step binding of mRNAs to the small ribosomal subunit depends on initiator tRNA and initiation factors, with far-reaching implications for posttranscriptional regulation of gene expression.
MeSH terms
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Fluorescence Resonance Energy Transfer
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Gene Expression Regulation
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Kinetics
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Nucleic Acid Conformation
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Peptide Chain Initiation, Translational*
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Protein Biosynthesis*
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RNA, Messenger* / chemistry
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RNA, Messenger* / genetics
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RNA, Messenger* / metabolism
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RNA, Ribosomal / chemistry
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RNA, Ribosomal / genetics
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RNA, Ribosomal / metabolism
Substances
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RNA, Messenger
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RNA, Ribosomal