Two-step selection of mRNAs in initiation of protein synthesis

Mol Cell. 2006 Apr 21;22(2):155-6. doi: 10.1016/j.molcel.2006.04.004.

Abstract

In a recent issue of Molecular Cell, Studer and Joseph (2006) clarified the molecular basis of the "standby model" and demonstrated how two-step binding of mRNAs to the small ribosomal subunit depends on initiator tRNA and initiation factors, with far-reaching implications for posttranscriptional regulation of gene expression.

Publication types

  • Comment

MeSH terms

  • Fluorescence Resonance Energy Transfer
  • Gene Expression Regulation
  • Kinetics
  • Nucleic Acid Conformation
  • Peptide Chain Initiation, Translational*
  • Protein Biosynthesis*
  • RNA, Messenger* / chemistry
  • RNA, Messenger* / genetics
  • RNA, Messenger* / metabolism
  • RNA, Ribosomal / chemistry
  • RNA, Ribosomal / genetics
  • RNA, Ribosomal / metabolism

Substances

  • RNA, Messenger
  • RNA, Ribosomal