Abstract
Helicases are molecular motors known to unwind double-stranded DNA. In a recent issue of Molecular Cell, Fan et al. (2006) revealed the core structure of XPB helicase, a component of transcription factor IIH, and proposed a mechanism for its dual role in transcription and nucleotide excision repair.
MeSH terms
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Amino Acid Motifs
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Amino Acid Sequence
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Archaeal Proteins / chemistry*
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Archaeal Proteins / genetics
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Archaeal Proteins / metabolism
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Archaeoglobus fulgidus / chemistry
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Binding Sites
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Conserved Sequence
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Crystallography, X-Ray
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DNA Helicases / metabolism*
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DNA Mutational Analysis
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DNA Repair*
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DNA-Binding Proteins / chemistry*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Models, Molecular
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Molecular Motor Proteins / metabolism*
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Molecular Sequence Data
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Mutation
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Protein Binding
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Protein Conformation
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Protein Structure, Tertiary
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Sequence Homology, Amino Acid
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Transcription, Genetic*
Substances
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Archaeal Proteins
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DNA-Binding Proteins
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Molecular Motor Proteins
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DNA Helicases