XPB: An essential helicase involved in both transcription and repair of DNA

Mol Cell. 2006 Apr 21;22(2):149-50. doi: 10.1016/j.molcel.2006.04.001.

Abstract

Helicases are molecular motors known to unwind double-stranded DNA. In a recent issue of Molecular Cell, Fan et al. (2006) revealed the core structure of XPB helicase, a component of transcription factor IIH, and proposed a mechanism for its dual role in transcription and nucleotide excision repair.

Publication types

  • Comment

MeSH terms

  • Amino Acid Motifs
  • Amino Acid Sequence
  • Archaeal Proteins / chemistry*
  • Archaeal Proteins / genetics
  • Archaeal Proteins / metabolism
  • Archaeoglobus fulgidus / chemistry
  • Binding Sites
  • Conserved Sequence
  • Crystallography, X-Ray
  • DNA Helicases / metabolism*
  • DNA Mutational Analysis
  • DNA Repair*
  • DNA-Binding Proteins / chemistry*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Models, Molecular
  • Molecular Motor Proteins / metabolism*
  • Molecular Sequence Data
  • Mutation
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary
  • Sequence Homology, Amino Acid
  • Transcription, Genetic*

Substances

  • Archaeal Proteins
  • DNA-Binding Proteins
  • Molecular Motor Proteins
  • DNA Helicases