Hybridization of pyrrolidinyl peptide nucleic acids and DNA: selectivity, base-pairing specificity, and direction of binding

Tirayut Vilaivan; Choladda Srisuwannaket

doi:10.1021/ol060448q

Hybridization of pyrrolidinyl peptide nucleic acids and DNA: selectivity, base-pairing specificity, and direction of binding

Org Lett. 2006 Apr 27;8(9):1897-900. doi: 10.1021/ol060448q.

Authors

Tirayut Vilaivan¹, Choladda Srisuwannaket

Affiliation

¹ Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand. vtirayut@chula.ac.th

PMID: 16623579
DOI: 10.1021/ol060448q

Abstract

[structure: see text] A mixed-base, beta-amino acid containing, pyrrolidinyl peptide nucleic acid (PNA) binds strongly and selectively to complementary DNA in an exclusively antiparallel fashion. The PNA-DNA binding specificity strictly follows the Watson-Crick base-pairing rules.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Pairing
Base Sequence
DNA / chemistry*
Molecular Structure
Nucleic Acid Hybridization
Peptide Nucleic Acids / chemical synthesis*
Peptide Nucleic Acids / chemistry
Pyrrolidines / chemistry*

Substances

Peptide Nucleic Acids
Pyrrolidines
DNA