The article presents different aspects of the connection between human heart and kidneys. This connection is evident in the symbolism of the Old Testament of the Bible, organ donation as the manifestation of the love of our neighbor, endocrinological and sexual dysfunction, and finally in searching for biological determinants of finer feelings. In the Old Testament tradition kidneys were thought to be human spirit's dwelling. Moreover, the simultaneous studying of kidneys and heart meant profound understanding of the matter. Nowadays, it is also possible to find the Biblical love of our neighbor, for instance among kidney donors. What is more, every nephrologist should treat his patients with love and dedication, which makes it easier for him to understand their problems, especially these concerning sexual dysfunction. Sexual dysfunction occurs among men and women equally and specialists, apart from using many different methods, have to deal with the consequences of renal failure mainly by means of transplantation.