Administration of antibody to the lung protects mice against pneumonic plague

Infect Immun. 2006 May;74(5):3068-70. doi: 10.1128/IAI.74.5.3068-3070.2006.

Abstract

Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

MeSH terms

  • Aerosols
  • Animals
  • Antibodies, Bacterial / administration & dosage*
  • Antibodies, Monoclonal / administration & dosage*
  • Antigens, Bacterial / immunology*
  • Bacterial Proteins / immunology*
  • Female
  • Mice
  • Mice, Inbred BALB C
  • Plague / prevention & control*
  • Pore Forming Cytotoxic Proteins
  • Yersinia pestis / immunology*

Substances

  • Aerosols
  • Antibodies, Bacterial
  • Antibodies, Monoclonal
  • Antigens, Bacterial
  • Bacterial Proteins
  • LcrV protein, Yersinia
  • Pore Forming Cytotoxic Proteins
  • caf1 protein, Yersinia pestis