Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice

Infect Immun. 2006 May;74(5):3016-20. doi: 10.1128/IAI.74.5.3016-3020.2006.

Abstract

Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Proteins / physiology*
  • Borrelia burgdorferi / genetics
  • Carrier Proteins / physiology*
  • Intracellular Signaling Peptides and Proteins
  • Lyme Disease / etiology*
  • Mice
  • Mice, Inbred C3H
  • Mice, SCID
  • N-Glycosyl Hydrolases / physiology*
  • Plasmids

Substances

  • Bacterial Proteins
  • Bgp protein, Borrelia burgdorferi
  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • N-Glycosyl Hydrolases