Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease

Tan Siew Kiat; Richard Pippen; Rohana Yusof; Halijah Ibrahim; Norzulaani Khalid; Noorsaadah Abd Rahman

doi:10.1016/j.bmcl.2005.12.075

Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3337-40. doi: 10.1016/j.bmcl.2005.12.075. Epub 2006 Apr 18.

Authors

Tan Siew Kiat¹, Richard Pippen, Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, Noorsaadah Abd Rahman

Affiliation

¹ Sunway University College, Bandar Sunway, 46150, P.J. Selangor, Malaysia.

PMID: 16621533
DOI: 10.1016/j.bmcl.2005.12.075

Abstract

Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chalcone / analogs & derivatives*
Chalcone / chemistry*
Chalcone / pharmacology*
Cyclohexanes / chemistry*
Cyclohexanes / pharmacology*
Flavonoids / chemistry*
Flavonoids / pharmacology*
Molecular Structure
Plant Roots / chemistry
Protease Inhibitors / chemistry*
Protease Inhibitors / pharmacology*
Serine Endopeptidases / metabolism*
Zingiberaceae / chemistry*

Substances

Cyclohexanes
Flavonoids
Protease Inhibitors
cyclohexenyl chalcone
Chalcone
NS3 protease, dengue virus
Serine Endopeptidases