Abstract
The capacity of malarial infection to suppress the patient's immune responses both to the parasite and to other antigens has long puzzled researchers. A prime suspect, the parasite-produced pigment hemozoin, has now been clearly shown to mediate immunosuppression by inhibiting dendritic cell activity.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Dendritic Cells / drug effects*
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Dendritic Cells / immunology
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Hemeproteins / metabolism
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Hemeproteins / pharmacology*
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Humans
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Immune Tolerance / drug effects
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Immunosuppressive Agents / metabolism
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Immunosuppressive Agents / pharmacology*
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Malaria / immunology*
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Mice
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Phagocytosis / drug effects
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Plasmodium / immunology
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Plasmodium / metabolism*
Substances
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Hemeproteins
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Immunosuppressive Agents
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hemozoin