Abstract
Passive transfer of a pediatric human serum pool generated against polysaccharide-protein D conjugate vaccines conferred approximately 34% protection against development of ascending NTHI-induced OM when used in a chinchilla viral-bacterial co-infection model. These data are in line with results obtained using a similar 11-valent-protein D conjugate vaccine in a pediatric clinical trial, wherein a vaccine efficacy of 35.6% was shown against acute OM episodes caused by NTHI. These observations strongly support the chinchilla passive transfer-superinfection model as one that could predict clinical trials outcomes for vaccines to prevent NTHI-induced OM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Intranasal
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Animals
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Antibodies, Bacterial / immunology*
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Bacterial Proteins / immunology*
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Carrier Proteins / immunology*
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Chinchilla
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Haemophilus Vaccines / administration & dosage
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Haemophilus Vaccines / immunology*
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Haemophilus influenzae / immunology*
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Humans
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Immune Sera / immunology
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Immunization, Passive*
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Immunoglobulin D / immunology*
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Lipoproteins / immunology*
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Nasopharynx / microbiology
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Otitis Media / prevention & control*
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Polysaccharides, Bacterial / immunology*
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Vaccines, Conjugate / immunology
Substances
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Antibodies, Bacterial
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Bacterial Proteins
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Carrier Proteins
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Haemophilus Vaccines
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Immune Sera
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Immunoglobulin D
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Lipoproteins
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Polysaccharides, Bacterial
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Vaccines, Conjugate
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glpQ protein, Haemophilus influenzae