Building bridges to the cortex

Cell. 2006 Apr 7;125(1):24-7. doi: 10.1016/j.cell.2006.03.021.

Abstract

Innervation of the neocortex by the thalamus is dependent on the precise coordination of spatial and temporal guidance cues. In this issue of Cell, work by López-Bendito et al.(2006) reveals that tangentially migrating cells within the ventral telencephalon are essential for axonal navigation between the thalamus and the neocortex, a process apparently mediated by Neuregulin-1/ErbB4 short- and long-range signaling.

Publication types

  • Comment

MeSH terms

  • Animals
  • Axons / metabolism*
  • Cell Movement*
  • Cerebral Cortex / cytology*
  • Cerebral Cortex / metabolism*
  • ErbB Receptors / metabolism
  • Neuregulin-1 / metabolism*
  • Receptor, ErbB-4
  • Signal Transduction
  • Thalamus / cytology*
  • Thalamus / metabolism

Substances

  • Neuregulin-1
  • ErbB Receptors
  • Receptor, ErbB-4