The complex combinations of Piroxicam (Pirox) with the metallic bio-ions: Cu(II), Co(II), Zn(II) have been obtained and defined in a previous stage by physical-chemical methods (IR, X, SM, CSS-UV, DTA, DTG), an toxicological and biochemical aspect. In this research are presented the results of the histological examinations at the level of stomach, for each compound, at 24 hours and at 7 days after the administration of the Piroxicam and of its complexes to rats. The tissues histo-pathological investigation has pointed out lesions the glandular stomach level (necrosis, ulcers) especially after the administration of the Piroxicam and of the Zn-Pirox complex. Name of these have been present after the administration of Cu-Pirox, Co-Pirox.