It is admitted that gastroesophageal reflux patients may presents ear, nose, and throat (ENT) symptoms and signs, condition known as laryngo-pharyngeal reflux. It is estimated that as many as 10% of patients presenting to an ENT specialist have a clinical condition that might be attributed to gastroesophageal reflux. The diagnosis is challenging since no laryngeal signs are pathognomonic. A combination of ENT and esophageal symptoms and signs may suggest the necessity of further investigations. Adapted 24h pH study or better an esophageal impedance study may reveal the involvement of gastroesophageal reflux. Alternatively, a short trial with omeprazole or another proton pump inhibitor may be the simplest way for diagnosis. The standard treatment for gastroesophageal reflux is the valid treatment for these patients.