Abstract
A female patient in whom acute nonlymphocytic leukemia (ANLL, FAB-M6) developed during treatment of hepatocellular carcinoma (HCC) is described. Two years after partial hepatectomy and subsequent chemotherapy, leukemia developed following a 2 month preleukemic stage. Chromosomal analysis revealed an abnormal karyotype, 46,XX,-5, + der(5)t(3;5)(q25;q31). The balanced translocation t(3;5) has been observed in all types of ANLL and MDS except for ANLL M3 subtype. We summarize patients with ANLL M6 and t(3;5).
MeSH terms
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Aclarubicin / administration & dosage
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Adolescent
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Adult
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Aged
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Anemia, Refractory, with Excess of Blasts / complications
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Carcinoma, Hepatocellular* / drug therapy
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Carcinoma, Hepatocellular* / etiology
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Carcinoma, Hepatocellular* / surgery
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Child
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Chromosomes, Human, Pair 3 / ultrastructure*
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Chromosomes, Human, Pair 5 / ultrastructure*
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Cytarabine / administration & dosage
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Daunorubicin / administration & dosage
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Doxorubicin / administration & dosage
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Female
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Hepatectomy
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Hepatitis B / complications
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Humans
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Leukemia, Erythroblastic, Acute / drug therapy
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Leukemia, Erythroblastic, Acute / genetics*
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Liver Neoplasms* / drug therapy
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Liver Neoplasms* / etiology
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Liver Neoplasms* / surgery
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Male
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Middle Aged
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Mitomycin / administration & dosage
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Mitomycin / therapeutic use
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Neoplasm Recurrence, Local
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Neoplasms, Multiple Primary*
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Prednisolone / administration & dosage
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Remission Induction
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Translocation, Genetic*
Substances
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Cytarabine
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Mitomycin
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Aclarubicin
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Doxorubicin
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Prednisolone
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Daunorubicin