Acute erythroleukemia with t(3;5) accompanied by hepatocellular carcinoma

Int J Hematol. 1991 Jun;54(3):213-7.

Abstract

A female patient in whom acute nonlymphocytic leukemia (ANLL, FAB-M6) developed during treatment of hepatocellular carcinoma (HCC) is described. Two years after partial hepatectomy and subsequent chemotherapy, leukemia developed following a 2 month preleukemic stage. Chromosomal analysis revealed an abnormal karyotype, 46,XX,-5, + der(5)t(3;5)(q25;q31). The balanced translocation t(3;5) has been observed in all types of ANLL and MDS except for ANLL M3 subtype. We summarize patients with ANLL M6 and t(3;5).

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aclarubicin / administration & dosage
  • Adolescent
  • Adult
  • Aged
  • Anemia, Refractory, with Excess of Blasts / complications
  • Carcinoma, Hepatocellular* / drug therapy
  • Carcinoma, Hepatocellular* / etiology
  • Carcinoma, Hepatocellular* / surgery
  • Child
  • Chromosomes, Human, Pair 3 / ultrastructure*
  • Chromosomes, Human, Pair 5 / ultrastructure*
  • Cytarabine / administration & dosage
  • Daunorubicin / administration & dosage
  • Doxorubicin / administration & dosage
  • Female
  • Hepatectomy
  • Hepatitis B / complications
  • Humans
  • Leukemia, Erythroblastic, Acute / drug therapy
  • Leukemia, Erythroblastic, Acute / genetics*
  • Liver Neoplasms* / drug therapy
  • Liver Neoplasms* / etiology
  • Liver Neoplasms* / surgery
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage
  • Mitomycin / therapeutic use
  • Neoplasm Recurrence, Local
  • Neoplasms, Multiple Primary*
  • Prednisolone / administration & dosage
  • Remission Induction
  • Translocation, Genetic*

Substances

  • Cytarabine
  • Mitomycin
  • Aclarubicin
  • Doxorubicin
  • Prednisolone
  • Daunorubicin