Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue

Uwe Zimmermann; Heike Junker; Fabian Krämer; Stefan Balabanov; Britta Kleist; Winfried Kammer; Alfred Nordheim; Reinhard Walther

doi:10.1515/BC.2006.058

Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue

Biol Chem. 2006 Apr;387(4):437-40. doi: 10.1515/BC.2006.058.

Authors

Uwe Zimmermann¹, Heike Junker, Fabian Krämer, Stefan Balabanov, Britta Kleist, Winfried Kammer, Alfred Nordheim, Reinhard Walther

Affiliation

¹ Department of Urology, University of Greifswald, Fleischmannstr. 42-44, D-17487 Greifswald, Germany.

PMID: 16606342
DOI: 10.1515/BC.2006.058

Abstract

A comparative proteomic analysis of neoplastic versus non-neoplastic seminoma identified glutathione S-transferase M3 as a differentially expressed protein. This expression difference could also be observed at the mRNA level, implying neoplasm-associated alterations in transcriptional or post-transcriptional mechanisms.

Publication types

Comparative Study

MeSH terms

Biomarkers / analysis
Biomarkers / metabolism
Electrophoresis, Gel, Two-Dimensional
Gene Expression Regulation, Neoplastic
Germ Cells / cytology
Germ Cells / enzymology*
Glutathione Transferase / analysis
Glutathione Transferase / genetics
Glutathione Transferase / metabolism*
Humans
Male
Mass Spectrometry
Proteomics
RNA, Messenger / metabolism
Seminoma / enzymology*
Testicular Neoplasms / enzymology*
Transcription, Genetic

Substances

Biomarkers
RNA, Messenger
GSTM3 protein, human
Glutathione Transferase