Abstract
A 3-year-old patient with biopsy-proven herpesvirus 6 (HHV-6) encephalitis developed a clinical condition consistent with systemic-onset juvenile idiopathic rheumatoid arthritis (SoJIA) and responsive to synthetic interleukin-1 (IL-1) receptor therapy. This suggested both a temporal relationship between HHV-6 infection and the development of SoJIA and the likely involvement of IL-1 in his disease. This case adds to the current experience of IL-1 receptor antagonist therapy in SoJIA. In addition, it suggests that future prospective studies in new-onset SoJIA should include an evaluation for HHV-6 infection.
MeSH terms
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Antirheumatic Agents / therapeutic use*
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Antiviral Agents / therapeutic use
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Arthritis, Juvenile / drug therapy*
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Arthritis, Juvenile / virology*
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Child, Preschool
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Encephalitis, Viral / drug therapy
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Encephalitis, Viral / virology
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Fever / drug therapy
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Fever / virology
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Ganciclovir / therapeutic use
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Herpesvirus 6, Human / isolation & purification
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Humans
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Interleukin 1 Receptor Antagonist Protein
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Male
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Receptors, Interleukin-1 / antagonists & inhibitors
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Roseolovirus Infections / complications*
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Roseolovirus Infections / drug therapy
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Sialoglycoproteins / therapeutic use*
Substances
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Antirheumatic Agents
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Antiviral Agents
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IL1RN protein, human
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Interleukin 1 Receptor Antagonist Protein
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Receptors, Interleukin-1
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Sialoglycoproteins
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Ganciclovir