Abstract
Development of new methods for the synthesis of beta-amino acids is important as polymers of these compounds are promising peptidomimetic candidates in medicinal chemistry. We report here our findings on a new and highly efficient general strategy for the synthesis of beta2-amino acids by homologation of alpha-amino acids, involving the Reformatsky reaction and Mannich-type imminium electrophile.
MeSH terms
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Amination
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Amino Acids / chemical synthesis*
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Amino Acids / chemistry*
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Bromine / chemistry
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Electrons*
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Esters / chemical synthesis
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Esters / chemistry
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Fluoroacetates / chemistry
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Mannich Bases / chemistry
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Methylation
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Molecular Structure
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Quaternary Ammonium Compounds / chemistry*
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Stereoisomerism
Substances
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Amino Acids
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Esters
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Fluoroacetates
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Mannich Bases
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Quaternary Ammonium Compounds
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fluoroacetic acid
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Bromine