Synthesis of indenes via palladium-catalyzed carboannulation of diethyl 2-(2-(1-alkynyl)phenyl)malonate and organic halides

Li-Na Guo; Xin-Hua Duan; Hai-Peng Bi; Xue-Yuan Liu; Yong-Min Liang

doi:10.1021/jo0601361

Synthesis of indenes via palladium-catalyzed carboannulation of diethyl 2-(2-(1-alkynyl)phenyl)malonate and organic halides

J Org Chem. 2006 Apr 14;71(8):3325-7. doi: 10.1021/jo0601361.

Authors

Li-Na Guo¹, Xin-Hua Duan, Hai-Peng Bi, Xue-Yuan Liu, Yong-Min Liang

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.

PMID: 16599642
DOI: 10.1021/jo0601361

Abstract

Highly substituted indenes have been prepared in good yields by the palladium-catalyzed carboannulation of diethyl 2-(2-(1-alkynyl)phenyl)malonate with aryl, benzylic, and alkenyl halides. The reaction conditions and the scope of the process were examined, and a possible mechanism is proposed.