Molecular recognition: improved binding of biotin derivatives with synthetic receptors

Fernando Herranz; M Dolores Santa María; Rosa M Claramunt

doi:10.1021/jo052424n

Molecular recognition: improved binding of biotin derivatives with synthetic receptors

J Org Chem. 2006 Apr 14;71(8):2944-51. doi: 10.1021/jo052424n.

Authors

Fernando Herranz¹, M Dolores Santa María, Rosa M Claramunt

Affiliation

¹ Departamento de Química Organica y Bio-Organica, UNED, Facultad de Ciencias, Senda del Rey 9, E-28040 Madrid, Spain.

PMID: 16599586
DOI: 10.1021/jo052424n

Abstract

NMR titrations and Monte Carlo conformational searches have been used to study the molecular recognition features of five urea derivatives with two synthetic hosts. We have improved the binding constant (Kb) values for all the studied guests and measured the largest binding constant of a complex involving a biotin derivative (biotin methyl ester) bound to a synthetic host by means of several interaction points and not only through the urea moiety.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomimetic Materials / chemical synthesis*
Biomimetic Materials / chemistry
Biotin / analogs & derivatives*
Biotin / chemistry
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Structure
Receptors, Growth Factor / chemistry*

Substances

Receptors, Growth Factor
biotin receptor
Biotin