Fluoroquinolone resistance in Ureaplasma parvum in the United States

Lynn Duffy; John Glass; Geraldine Hall; Robin Avery; Raymond Rackley; Scott Peterson; Ken Waites

doi:10.1128/JCM.44.4.1590-1591.2006

Fluoroquinolone resistance in Ureaplasma parvum in the United States

J Clin Microbiol. 2006 Apr;44(4):1590-1. doi: 10.1128/JCM.44.4.1590-1591.2006.

Authors

Lynn Duffy¹, John Glass, Geraldine Hall, Robin Avery, Raymond Rackley, Scott Peterson, Ken Waites

Affiliation

¹ Department of Pathology, WP 230, 619 19th St. South, University of Alabama at Birmingham, Birmingham, AL 35226, USA.

Abstract

We report the first case of naturally occurring fluoroquinolone resistance in Ureaplasma spp. from the United States. Resistance in this case probably developed as a result of mutations in the gyrA and parC genes of the DNA gyrase/topoisomerase IV complex that occurred in the presence of antimicrobial selective pressure.

Publication types

Case Reports

MeSH terms

Adult
DNA Gyrase / genetics
DNA Topoisomerase IV / genetics
Drug Resistance, Bacterial*
Female
Fluoroquinolones / pharmacology*
Humans
Microbial Sensitivity Tests
Mutation / genetics
United States
Ureaplasma / drug effects*
Ureaplasma / genetics
Ureaplasma / isolation & purification
Vagina / microbiology

Substances

Fluoroquinolones
DNA Topoisomerase IV
DNA Gyrase