Cholinesterase inhibitors: drugs looking for a disease?

PLoS Med. 2006 Apr;3(4):e140. doi: 10.1371/journal.pmed.0030140. Epub 2006 Apr 11.

Abstract

Maggini and colleagues examine the evidence on cholinesterase inhibitors for treating dementia. "What seemed a biologically plausible intervention," they say, "has not led to a proven, real improvement in patients' well-being."

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Cholinesterase Inhibitors / therapeutic use*
  • Cognition Disorders / classification
  • Cognition Disorders / drug therapy*
  • Dementia, Vascular / drug therapy*
  • Drug Industry
  • Evidence-Based Medicine
  • Humans
  • Lewy Body Disease / drug therapy*
  • Parkinson Disease / complications
  • Randomized Controlled Trials as Topic
  • Reproducibility of Results
  • Risk Factors
  • Treatment Outcome

Substances

  • Cholinesterase Inhibitors